Synthesis of gem-difluorocyclopropa(e)nes and O-, S-, N-, and P-difluoromethylated compounds with TMSCF(2)Br.

نویسندگان

  • Lingchun Li
  • Fei Wang
  • Chuanfa Ni
  • Jinbo Hu
چکیده

Two-in-one: Me3 SiCF2 Br is an efficient difluorocarbene source and is compatible with both neutral and aqueous basic conditions. Bromide-ion-initiated [2+1] cycloaddition with alkenes/alkynes and hydroxide ion promoted α-addition with (thio)phenols, (thio)alcohols, sulfinates, heterocyclic amines, and H-phosphine oxides give the corresponding gem-difluorinated compounds with broad functional-group tolerance.

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عنوان ژورنال:
  • Angewandte Chemie

دوره 52 47  شماره 

صفحات  -

تاریخ انتشار 2013